????????????? ???, ??????? ?, ????? ???, ????-?????? ?, ?????? ?, ?????? ??, ??????? ???, ???????? ???, ???????? ?, ?????????? ??, ??????? ?, ???? ?, ?????? ???, ????????-??????????? ???, ?????? ??? ????? ??????? ??
???????: BRCA1/2 ?????????? ????????????? ???? ???????? ??????????? ????????-?????????? (BSO) ???????????? ???? ??????????? ????? ?????????? (PSC) ????? ????? ????????? ????????????. BRCA1/2 ????????? ???????????? BSO ?????? PSC ??????????? ?????????? ??????? ????? ?????? ???????? ???????????? ???? ????????? ??????????????.
????????: PSC ????? ????? ????????? ???? BSO ???????????? ???-??????? BRCA1/2 ????????? ??????????? ?????????? ??????????. ??????????? ??????? ????????? ?????? ?????????? (FTC), ?????? ?????????? (OVC) ????? ????? ??????? ??????????????? ?????????? (STIC) ???? BSO ??????? ?????????? ??????????. 58 ???? ??????? P53 ????? ?????????? ????. ????? ??????? ????? ????????? ???? ??????????. ???? BSO ?????? PSC ????? ?????????, ?????????? ????? ??????????? ?????? ?????? ???? ??????????? ???????????.
???????: BSO ?????? ?????????? 1 ???? (0.8%), STIC 2 ???????? (1.7%), ????? 6/58 ?????? (10.3%) ??????? “p53 ?????” ????? ???? ??????? FTC?? ??????? ???????. ?????????? ????? ?????? (p=0.007) ????? ?????? ???? ?????????? ???????? (p<0.001) FTC ????? STIC??? ?????? ????? ??????. BSO ?????? PSC ????? 1.7% (?????? ??????). ????? BRCA2 ????????? ??????????? ????? ?????? STIC ?????? ????. BSO ?????? PSC ???? ???????????? ???? ?????? ????? ??????????????? ????? ?????? (PSC ???? ??????? 63.5 ?????????? ????? PSC ???? ??????? 48.6 ??????????, p<0.001).
??????????: ?? ???????? BSO ?????? PSC ????? 1.7% ????? ??? BSO?? ??? ???????? ?????? ????? ???????. ?????????? ????????? ????? ???? ?????????? ???????? ??????? FTC ????? STIC? ??????????? ????????? ?????? ????? ???????? ????????????.
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