Harris Scott*
Vasculitis, a heterogeneous group of disorders characterized by inflammation of blood vessels, has long been recognized as having a genetic component in its pathogenesis. This comprehensive review explores the intricate interplay of genetic factors in vasculitis, shedding light on recent advancements and their implications for understanding, diagnosing, and treating these complex diseases. Collaborative research between geneticists and rheumatologists has identified a strong genetic basis for vasculitis. Genome-wide association studies have uncovered specific genetic variants associated with different forms of vasculitis, providing key insights into the molecular mechanisms underlying these disorders. Understanding the genetic foundation is crucial for unraveling the pathogenesis of vasculitis. The collaborative efforts of immunologists and geneticists have revealed significant associations between human leukocyte antigen alleles and susceptibility to vasculitis. Certain HLA genes are implicated in increased risk or protection against specific forms of vasculitis. Investigating these associations deepens our understanding of immune dysregulation in vasculitis and guides research toward targeted therapies.
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