Martine KF Docx, Annik Simons, José Ramet, Luc Mertens and Paul Govaert
The estimated prevalence of secondary and tertiary (central) adrenal insufficiency is 150-280 per million [1]. A lot of processes that involves the hypothalamus and which interferes with CorticotrophinReleasing Hormone (CRH) secretionare hypothalamic tumors, surgery, irradiation and autoimmune hypothalamic disease will result in central adrenal failure.
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