Mavin Louis*
Hyaluronan is a straight sugar biopolymer composed of a single disaccharide of -D-glucuronate (GlcA) and N-acetyl-D-glucosamine (GlcNAc). Unlike other glycosaminoglycans discovered in humans, such as chondroitin/dermatan and heparan/heparin, GlcA monosaccharides in hyaluronan are not subjected to enzymatic epimerization to -L-iduronate (IdoA). Furthermore, unlike the glycosaminoglycans chondroitin/dermatan sulphate, heparan sulphate, heparin, or keratan sulphate, hyaluronan is not enzymatically sulfated. While these characteristics make hyaluronan less challenging to work with than the other glycosaminoglycans, hyaluronan is still a highly versatile particle.
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