M Sefidgar, M Soltani, H Bazmara, M Mousavi, M Bazargan and A Elkamel
Interstitial fluid flow has been studied by many cancer researchers for investigation of how interstitial flow can
affect drug delivery. This paper couples blood flow through a capillary network induced by tumor angiogenesis and
fluid flow in interstitium and investigates the effects of consideration of a remodeled network and adaptability of
capillary on interstitial flow. Two approaches are studied for showing the remodeling effects. In the first approach,
the capillary network is presumed to have capillary with constant diameter. For the second approach, the adaptable
capillaries are assumed in which the metabolic and hemodynamic stimuli changes capillary’s diameter based on
sending signals to capillary. Numerical results show that the intravascular pressure has more uniform distribution
along the network and capillary diameter has greater value in the network. The prediction of interstitial pressure for
the second approach shows higher values compared to the first approach. Results from interstitial flow and blood
flow distribution in normal and cancerous tissues have beneficial information about prediction of successive drug
delivery.
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