Wael M El-Deeb and Taha A Fouda
Background: The characteristic clinical manifestations, oxidative stress markers and proinflammatory Cytokines in liver abscess in camel are poorly defined.
Objective: The objectives of this study were to investigate liver abscess in camel at the slaughter house and to address its effect on blood cellular and biochemical values particularly oxidative stress markers and proinflammatory cytokines.
Methods: Thirty-five camels with liver abscess and 15 healthy camels were included in this study. Complete blood picture, and selected biochemical parameters were carried out. Bacteriological examination was also carried out.
Results: Clinical signs were recorded. The hematological picture of diseased camels revealed reduction in the total erythrocytic count and hemoglobin level associated with elevation in leucocytic count and neutrophils percentage. The biochemical analysis of serum samples revealed increase in the levels of liver enzymes associated with reduction in the levels of total proteins, albumen and glucose levels in diseased camels when compared to their levels in healthy ones. Increased levels of lipid peroxidation and glucose 6-phosphate dehydrogenase with significant reduction in the levels of superoxide dismutase, catalase and glutathione were evident when compared to their levels in healthy camels. There was elevation in the levels of TNF-α, IFN-γ, IL-1α, IL-1β, IL-6 and IL-10 in diseased camels when compared to their levels in normal ones. The isolated bacteria from liver abscess were Fusobacterium necrophorum, Corynebacterium psuedotuberclosis, Escherichia coli, and Staphylococcus spp.
Conclusions: Oxidative stress and proinflammatory Cytokines could be used as biomarkers of liver abscess in camel.
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