జర్నల్ ఆఫ్ ఇంటిగ్రేటివ్ ఆంకాలజీ

Long Term Remission of a Primary Intracerebral Hodgkin Lymphoma in a Patient Previously Treated With Azathioprine

Abstract

Santiago Mercadal, Fina Climent, Nadia García and Eva González-Barca

Background: primary central nervous Hodgkin Lymphoma is a very rare event that occurs in less than 0.2% of cases, most of them in immunosuppressed patients.
Case presentation: We describe a 59 year-old man with a 20 year history of ulcerative colitis treated with azathioprine during 6 years who developed a primary central nervous system Hodgkin Lymphoma. Inmunohistochemical study was positive for Epstein-Barr virus showing a type II latency pattern. The patient was treated with chemotherapy regimen consisting on high dose methotrexate and cytosine arabinoside achieving complete remission that remains more than five years after diagnosis.
Conclusions: To the best of our knowledge we present the first case in the literature of a primary central nervous system hodgkin lymphoma in a immunossupressed patient due to azathioprine with a long remission after chemotherapy alone.