Lei Fan*
Most marketed HA-based dermal fillers use chemical cross-linking to improve mechanical qualities and extend in vivo lifetime; nevertheless, stiffer formulations with greater elasticity necessitate a higher extrusion force for injection in clinical practise. To strike a balance between longevity and injectability, we suggest thermosensitive dermal filler that is injectable as a low viscosity fluid that gels in situ upon injection. In order to achieve this, HA was attached via a linker to poly (N-isopropylacrylamide) (pNIPAM), a thermosensitive polymer, using "green chemistry" and water as the solvent. At normal temperature, HA-L-pNIPAM hydrogels had a relatively low viscosity (G′ was 105.1 and 233 for Candidate1 and Belotero Volume, respectively) and spontaneously produced a stiffer gel with submicron structure at body temperature. Hydrogel compositions were found to be more resistant to enzymatic and oxidative breakdown.
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