సైటోలజీ & హిస్టాలజీ జర్నల్

Pattern of Chromosome Abnormalities Related to Male Infertility in Senegal: A Prospective Study of 67 Cases

Abstract

Mama Sy*, Abdoulaye Séga Diallo, Racha Kamenda Ibondou, Mame Vénus Gueye, Ndiaga Diop, Adji Djeynaba Diallo, Abdoulaye Ba and Oumar Faye

Introduction: Infertility may result from male or female factors or a combination of both. It is known that male factors are responsible for 50% of all infertility. Genetics is part of the management of male infertility, and karyotyping is highly recommended in men with nonobstructive azoospermia, severe oligozoospermia (sperm count <5 million/ml), or no palpable vasa. The purpose of our study was to determine the prevalence and profile of the chromosomal abnormalities of this subgroup in a cohort of patients followed for male infertility in the laboratory of cytogenetics and reproductive biology at the University Hospital Center Aristide Le Dantec in Dakar, Senegal.

Material and methods: Sixty-seven (67) patients with primary infertility were selected for our study. After semen analysis and evaluation of serum levels of FSH, a standard karyotype with R banding was performed.

Results: The global prevalence of chromosome abnormalities was 16.41% (n=11), with essentially numerical abnormalities (n=10). In terms of prevalence, Klinefleter syndrome was the most represented abnormality, with a global prevalence of 11.93% and a frequency of 2.988% in mosaic forms. Were also registered, respectively, a case of 47, XYY, and a case of XX male, 46,XX.

Conclusion: Primary infertile males with NOA and severe oligozoospermia have a non-neglectable rate of chromosomal aberrations, justifying the requirement of cytogenetic testing in order to pursue assisted reproductive treatment.