న్యూక్లియర్ మెడిసిన్ & రేడియేషన్ థెరపీ

The Effect of BMI and Visceral Fat Percentage on the Development of Bone Metastases in Prostate Cancer

Abstract

Fusun Aydogan, Ebuzer Kalender, Murat Rifaioğlu M, Taner Sümbül A and Erhan Yengil

Abstract
Introduction: Prostate cancer (PCa) second leading cause of cancer-related deaths among men worldwide. There are publications in the literature examining the relation between obesity and PCa, but there is not publication about the relation between obesity and bone metastases in PCa. The aim of this study is to determine whether there is a relation between bone metastasis, PSA, Gleason score, BMI and visceral fat percentage (VFP) in PCa patients.
Methods: Thirty-four patients with PCa who performed bone scintigraphy included to study. Mean age was 71.3 ± 6.9 years. All patients' height, weight, VFP and BMI were calculated. PSA levels, Gleason scores, VFP and BMI of patients with and without bone metastases were compared.
Results: On the bone scintigraphy 14 patients had bone metastasis and there was no metastases in 20 patients. PSA levels and Gleason scores were higher in patients with bone metastases than in patients without bone metastases and this was statistically significant (p= 0.004). While the BMI level was 26.15 kg/m2 (22.7-33.5) in patients with bone metastasis, it was 26.5 kg/m2 (20.7-43.9) in patients without bone metastasis. VFP was 11 (6-27) in patients with bone metastasis and 9 (3-17) in patients without bone metastasis. Although the VFP was higher in patients with bone metastases; this was not statistically significant (p=0.15).
Conclusion: Our data suggest that there is a significant correlation between bone metastasis and high Gleason score and PSA level, but there is not significant correlation between bone metastasis and BMI, VFP in PCa.