జర్నల్ ఆఫ్ ఇంటిగ్రేటివ్ ఆంకాలజీ

Drug resistance is a major challenge in the treatment of cancer. It refers to the ability of cancer cells to survive and continue growing despite exposure to anti-cancer drugs. This uncontrolled growth can result in the formation of a lump or mass called a tumor. These are non-cancerous growths that do not invade nearby tissues or spread to other parts of the body. They tend to grow slowly and are usually not life-threatening. In some cases, cancer cells are inherently resistant to certain drugs. This is known as intrinsic or primary resistance. The genetic makeup of these cells may make them less susceptible to the drug's mechanism of action.

The research project aimed at investigating the role of microRNA 138 (miR-138-5p) in the regulation of pancreatic cancer cell growth and its potential as a therapeutic target. Let's break down the key points: The passage acknowledges the dismal prognosis associated with pancreatic cancer, highlighting that limited progress has been made in its diagnosis and treatment over recent decades. This emphasizes the urgency and importance of research in this area. The primary objective of this study is to understand the role of miR-138-5p in the context of pancreatic cancer. MicroRNAs are small RNA molecules that can influence gene expression, and investigating their role in cancer is a common area of research. Pancreatic cancer is indeed one of the most challenging types of cancer, primarily because it is often diagnosed at an advanced stage when treatment options are limited, and it has a poor prognosis.

Cancer is a revolutionary approach to treatment that harnesses the body's own immune system to recognize, attack, and destroy cancer cells. Unlike traditional cancer treatments such as chemotherapy and radiation therapy, which directly target cancer cells, immunotherapy works by stimulating or enhancing the body's natural immune response against cancer. The immune system is a complex network of cells, tissues, and organs that defends the body against infections and diseases, including cancer. However, cancer cells can sometimes evade detection by the immune system. ver the years, various immunotherapies have been developed and approved for the treatment of different types of cancer. Some of the most notable ones include pembrolizumab and nivolumab (checkpoint inhibitors), as well as CAR T-cell therapies like Kymriah and Yescarta. Immunotherapy has shown remarkable success in treating some types of cancer, leading to long-lasting remissions or even cures in certain patients. It has particularly been effective in melanoma, lung cancer, and some forms of leukemia and lymphoma.

Several cutting-edge technologies were being applied in the field of cellular oncology, or the study of cancer at the cellular and molecular level. It's important to note that the field of oncology is constantly evolving, and new technologies are continually emerging. Plasma is a component of blood that contains water, electrolytes, hormones, waste products, and proteins, According to GLOBOCAN data, 14.1 million new cases and 8.2 million deaths from cancer were estimated in 2012.1 Cancers of the female breast, colorectal, prostate, and lung are the most frequently diagnosed cancers in Europe.2 Lung cancer remains the leading cause of cancer incidence and mortality worldwide.

Objective: Breast cancer is the most common type of cancer and the second leading cause of cancer death among women. Early detection of breast cancer leads to almost complete cure. Breast cancer screening includes breast self-examination, clinical breast examination, and mammography.

Methods: This is an interventional (descriptive) study. The study population was 400 female employees working for 20 years-45 years under the auspices of Shushtar health centers. Which were randomly divided into two groups of intervention (n=100) and control (n=100). The educational intervention was performed in two sessions of 60 minutes. Data were collected by completing a questionnaire as well as a performance checklist during a direct interview before the educational intervention and two months after. After co-ordination with all health centers in Shushtar city and making available the population of women working staff aged 20 years-45 years, sampling was performed in two stages. In order to analyze the data using SPSS software. Ver 25. To describe the data, frequency, percentage, mean and standard deviation, ANOVA and paired analysis test will be used.

Results: 400 women working in comprehensive health centers in Shushtar city were investigated in this study. Most of the surveyed working women were 35 years-40 years old (32/5) 130. The highest rate of marital status of working women is married (60) 240. Likewise, the results showed that the education level of most working women (45) was 180 of the participants in the bachelor study. The results of the ttest showed that there was a significant difference between all the components of breast self-examination before and after the intervention. The results of the paired t-test showed that there was a significant difference between all the components of breast self-examination before and after the intervention.

Conclusion: BASNEF model was effective in breast self-examination training in women aged 20 years-45 years in Shushtar comprehensive health centers and increased the scores of knowledge, attitude, abstract norms, enabling factors and performance.