జర్నల్ ఆఫ్ ఆంకాలజీ మెడిసిన్ & ప్రాక్టీస్

Radiation-associated colon cancer is a rare clinical entity. We herein describe the case of a patient with radiation-related colon cancer who had gone through low anterior resection for rectal cancer following preoperative radiotherapy. Few characteristics of radiation?? related colon most cancers are highlighted.

Objectives: The Primary aim of this study is to assess the outcome of children with solid and CNS tumors who underwent HDCT and ASCT at King Fahad Specialist Hospital in Dammam, secondarily we aim to compare our local results with national and international outcomes, Identify the toxicities, and complications of this modality of treatment, and identify the outcome in term of overall survival and relapse and mortality rates.

Design: This is a retrospective cross-sectional study of all the pediatric patients below sixteen-year-old who diagnosed with solid tumor or central nervous system tumor and treated by high dose chemotherapy and autologous stem cell transplantation in king Fahd specialist hospital in Dammam, pediatric hematology/ oncology department between 1^st November 2011 and 29^th February 2020, our study included 33 cases.

Setting: It is a single center study at King Fahad Specialist Hospital in Dammam which is 400 beds tertiary referral hospital with 27 beds pediatric oncology Ward, 4 beds bone marrow transplant and 18 bed pediatric oncology day care services.

Methods and Results: After obtaining the IRB approval, all data and information of patients were retrieved from patients’ hard files and electronic medical records. Data analysis were done by using Statistical Package for the Social Sciences (SPSS) program version and stored in the Redcap system for confidentiality.

Results: Within our study period we diagnosed 33 cases who diagnosed with solid tumor or central nervous system malignancies and treated by high dose chemotherapy and autologous stem cell transplantation in king Fahd specialist hospital in Dammam, the overall survival was 66% with both the relapse rate and mortality rate were 33%.

Conclusion: In summary, despite being a single-center experience and relatively small sample size, yet we believe that our study showed that the approach of using HDCT followed by APBSCT for managing children with advanced malignant solid tumors is safe and effective with the best results obtained in those with complete remission status before that approach. A prospective study will be more suitable to evaluate whether HDCT with auto�??PBSCT will significantly impact the outcomes in the treatment of children with advanced malignant solid tumors. a serious international collaboration is crucial to design randomized trials aiming to address these expensive and high morbidity procedures in treating childhood advanced solid malignant tumors.

Objective: Medulloblastoma is the most common malignant brain tumors in children worldwide. It is little known about the characteristics associated with medulloblastoma and the outcome in Saudi Arabia. Therefore, the study was conducted to understand the current status and what should be done for future.

Methods: A retrospective chart review of all children (<14 years) who have been diagnosed and managed with medulloblastoma at King Faisal specialist hospital and research center (KFSHRC) in Jeddah, Saudi Arabia from 2011 to 2017. Important epidemiological and clinical Data have been collected and analyzed through descriptive statistics to understand the clinical characteristics and treatment outcomes. In addition, Kaplan-Meier survival analysis was conducted to generate EFS and OS.

Results: The obtained results of OS of 73.7% with suggested that lower age (Age ≤ 3), high risk, positive metastasis at presentation, partial resection remained vital and contributed to lower overall survival rate among the patients with P value as follow: (P:<0.001, P:0.041, P:0.020, P:0.006). Moreover, event free survival rate was 54.8% and analysis of it suggested that the extent of complete surgical resection (P<0.018) and age >3 years (P<0.001) was the major factor for better survival.

Conclusion: As per the observation, the estimated outcome of total cohort was OS 73.7% and EFS 54.8% which are comparable to the developed countries. The age of > 3 years and the complete surgical excision are emerging as the most significant factors affecting OS (80.5%, 88.7%) and EFS (61.2%, 70%). Average risk and negative metastasis had significant OS with p value of 0.04, 0.02 respectively. This study provides an important clue in understanding the importance of the demographic, clinical, and treatment modalities in understanding the prognosis of medulloblastoma. This report will serve as an important resource from Kingdom of Saudi Arabia regarding medulloblastoma survival.