Achudume AC
The widespread use of pesticides has numerous pathological consequences including agents which generate oxidative stress. Analysis of impacts of pesticides and oxidative stress provide available evidence that suggests changes that play a key role in various conditions which limit the human life span. Ingestion of insecticide Raid® was administered to wistar rats for 30 and 60 days and various target organs of rats were examined for oxidative stress profile. Results showed that all the parameters either in erythrocyte or the organs compared negatively with the control groups (P<.05). The results indicated that catalase, superoxidedimutase (SOD), glutatathione reductase (Gr), and glutathione (GSH) levels significantly decreased in rats treated with insecticide Raid® alone compared with the liver and kidney. Besides, raid-induced oxidative damage caused a significant increase in malondialdehyde (MDA) levels of the liver and kidney tissues. Even more disturbing is the fact that pesticide is typically associated with cellular dysfunction as discussed.
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