Kaushik D, Kaushik P and Khokra SL
In the present study we investigated the possible anti-diabetic potential of Pinus roxburghii Sarg. in alloxan induced diabetic rat. Diabetes was induced in rats by injecting them with alloxan (120 mg/kg body weight). Control rats were either healthy untreated, or diabetes induced untreated rats which only received distilled water. The acute effect of ethanol extract was evaluated by administering 100, 300, 500 mg/kg body weight p.o. to normoglycemic rats. In the chronic model, the ethanol extract was administered to normal and alloxan-induced-diabetic rats at dose of 100, 300, 500 mg/kg body weight p.o. per day for 21 days. Blood glucose levels and body weights were monitored at specific intervals and different biochemical parameters were also carried out. The statistical data indicated the significant (p<0.01) increase in the body weight and decrease in the blood glucose, glycated hemoglobin levels, total cholesterol and serum triglycerides. HDL cholesterol level was significantly (p<0.01) increased when treated with the extract. Quercetin isolated from the bark of plant showed α-amylase inhibitory activity .Hence, it can be concluded that antihyperglycemic and antihyperlipidemic activities of ethanol extract of Pinus roxburghii Sarg. Bark may be due to the presence of phytoconstituents like flavanoids.
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