Kamarapu P, Sailakshmi P
The majority of the population in developing countries uses plants or plant preparations in their basic health care. Many plant species have been proved to have antimicrobial activity. Lots of the antibiotics had been at the beginning derived from micro-organisms even as the chemotherapeutic agents are from vegetation. Together with other dosage varieties, natural drugs are additionally formulated within the type of ointment. An ointment is a viscous semisolid preparation used topically on a variety of body surfaces. Thus, the main objective of the present study is to formulate and evaluate a polyherbal ointment with antimicrobial activity. Ointments were formulated using methanolic extracts (by continuous hot percolation-soxhlation) of Shatavari, Terminalia chebula and were evaluated for its physicochemical properties. The methanolic extracts of the chosen plants were taken in specific ratio randomly and the antimicrobial tests of the combinations had been applied. Ointments were all set making use of special concentrations of the extracts with the aid of fusion procedure utilizing emulsifying ointment as a base. Formulations had been then tested for its physicochemical properties like loss on drying, pH, spread ability, extrudability and gave satisfactory results. Probably the most powerful mixture used to be then determined via evaluating the results of the zone of inhibition given through distinct extract ratios on Escherichia coli, Staphylococcus aureus of antimicrobial undertaking against various gram positive and gram terrible. The entire formulations confirmed predominant recreation against selected species. The formulations are found to be very efficacious in all the parameters which has conducted and also found enhance antimicrobial property. Overall result of this study reveals that this is an effective polyherbal antimicrobial ointment.
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