మాలిక్యులర్ మరియు జెనెటిక్ మెడిసిన్

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social communication and repetitive behaviors. While genetic factors play a significant role in ASD, emerging evidence suggests that environmental factors, including drug exposure during pregnancy, can also contribute to its etiology. Glial cells, once considered mere support cells in the brain, are now recognized as key players in neuronal function and neurodevelopment. Additionally, epigenetic mechanisms, such as DNA methylation and histone modifications, have been implicated in the pathogenesis of ASD. This article explores the functions of glial cells and epigenetic processes in drug-induced ASD, highlighting their interplay and potential therapeutic implications.

Nanoparticles have garnered considerable interest in the field of antiviral therapeutics due to their unique properties and potential applications. Among these, cerium oxide (ceria) nanoparticles have shown promise as a novel antiviral agent, demonstrating durable, strong, and broadspectrum activity against RNA viruses. This paper explores the mechanism by which ceria nanoparticles target virion surfaces, leading to the inactivation of viral infectivity. By interfering with virus-receptor interactions, ceria nanoparticles disrupt crucial steps in the viral lifecycle, offering a promising avenue for the development of effective antiviral strategies.

???????? ??????-?????????????? ????????????? (PTM??) ?????????? ????????? ????? ?????????? ???????????, ???????? ???????, ??????????? ????? ?????? ??????? ????????? ????????. O-GlcNAcylation, N-acetylglucosamine (GlcNAc)?? ????????? ?????? ???? ?????????? ????????? ????????, ???????, ????????? ????? ????????????????‌?? ??? ????? ????????? ????????? ????? ??????? ????? ??????????? PTM. ?????????? ?????????? ????? ?????? ???????????‌?? ???? ???????? ????? ????????????? O-GlcNAc ????‌? ????? ????????? ????? ?????. ???? ???????????????? ???? O-GlcNAc ????‌??? ?????????????? ????????? ??????????? ???????? ???? ??????????? ????? ????????. O-GlcNAcylatio ????? ?????-?????? ?????????? ??????? ??????, ??? ???????? ??????? ????????? ????? ??????????? ????????????????? ??????????.

?????????? ????????? ?????‌??????? ????????? (CPER) ????? ?? ?????????? ??????????? ????????, ??? ???????????? ???????????‌? ????? ????????? ????? ??????????? ?????????? ?????????????. ? ?????? ????????? DNA ?????????‌?? ????? DNA ????????? ????? ??????? ??? ??????????? ????? ?????????? ??????????????? ????? ?????????????? ?????????????, ????????? ????????? ????????? ???????? ????, ??????????? ????? ????? ????? ??????????? ???????????. ? ????? ????????, ???? Flavivirus ??????? ????????? CPER ????? ????????, ??????????? ????? ?????? ????????? ?????????????. ???? ?????????, ?????????? ????????? ????? ?????????? ????? ?????????? ???? ??????? ??????????? ???? ???????????. ????, ???? CPER-?????? ??????? ????? ??????? ????? ?????????? ?????? ?????????????, ?? ???????? ?????????????? ????? ??????????? ??????????‌??? ???????????? ???? ???????????? ?????? ????????.

???? ???????? ???????? ?????????? ?????? ??????????????, ????? ??????- ???? ????????????????? ??????????????, ???? ?????????? ????????? ?????????? ????????????? ???? ???-?????? ????????????? (IVF) ????????? ?????????. ????? ??? 10-15 ?????????? ?? ???? ??????????? ???????? ??????????? ?????????. ????? ?????? ??????, ????? ??????? ???? ??????? ????????????? (WES) ???????????????, ??? ???????????? C ???? 1 (PLCζ1) ????????? ?? ?????????‌?? ?????????????. ? ???????? ???? ???????? ?????????? ????? ???????? ?????? ???????, ????? ?????? ???? ????????????? ????????? ???????? ??????? ???????????????.

PLCζ1 ???????, ?????????? 12?? ????, PLCζ1 ?????? ?????????? ???????????????. ? ?????? ????????? ????????????? ????? ?? ???? ????????????, ??????? ?????? ???????? ??????????‌?? ?????????????? ???? ????? ???????????. PLCζ1 ???????? ?????? ????????? ?????????????? (IP3) ?????????? ??????? ?????????, ???????? ????? (Ca ²⁺ ) ????? ??????????‌?? ???????????? ?????? ???????? ???? ???????? ???????, ?????? ?????????? ????? ???????? ????? ?????? ????????? ??????? ???.

???? ????? ?????? ???????? ????????, ???????? ??????? ??? ????????‌?? ?????????????? ????????????. ???????????, ?????? ?????? ????????????? ???????, ?????? ????????? ????? ???????????. ? ??????? ?????????? ?? ?????/???? ?? ????????? ????? ???????? IVF ???????? ??????? ?????????????? WES ???????? ????? ???????????? ???????????.