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జర్నల్ ఆఫ్ నెఫ్రాలజీ & థెరప్యూటిక్స్

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వాల్యూమ్ 11, సమస్య 10 (2021)

చిన్న కమ్యూనికేషన్

Global Nephrology: A Significant Role to Decrease the Incidence of Renal Injuries after Lung Transplantation

Lucy Lu

Lung transplantation has been progressively performed worldwide and is viewed as a viable treatment for patients with various causes of end-stage lung diseases. We played out a precise survey to evaluate the occurrence and effect of kidney injury and requiring Renal Replacement Therapy (RRT) in patients after lung transplantation. With the improvement of survival after LT and the increasing number of lung transplant recipients, the detrimental impact of current management on renal function has become increasingly apparent.
పరిశోధన వ్యాసం

NGAL-A Promising Biomarker for AKI in Severe COVID-19 Disease and Its Prognostic Role: A Prospective Study

Anubhuti Bhardwaj1*, Upma Narain2 and Arvind Gupta1

Background: COVID-19 disease has stunned the world with its relentless spread and high mortality rates. Acute kidney injury has been an important consequence of the disease, contributing to mortality. There is unavailability of data for using neutrophil gelatinase associated lipocalin as a biomarker for acute kidney injury in patients with severe COVID-19 disease.

Aim: To evaluate the role of inflammatory marker neutrophil gelatinase associated lipocalin in severe COVID-19 disease.

Methods: A prospective observational study was conducted at various tertiary care hospitals in Prayagraj from January 1st 2021 to March 15th 2021, which included only patients with severe COVID-19 disease requiring ICU admission. Patients of known renal diseases were excluded from the study. The study was done on 110 patients, out of which 5 patients were excluded. Blood as well as urinary samples for neutrophil gelatinase associated lipocalin and the other laboratory parameters were collected within 8 hours of admission. The patients were followed until the hospital stay, and investigations were repeated every 3 days. The primary outcome was development of acute kidney injury, while secondary outcomes included-need of renal replacement therapy such as hemodialysis, mortality. Patients who developed renal dysfunction were noted as our cases and the others were noted as controls.

Results: The study was done on 105 patients, out of which 60 developed AKI (Acute kidney injury) and were noted as cases while 45 were our controls. The cutoffs for serum and urinary neutrophil gelatinase associated lipocalin for predicting acute kidney injury were found to be >91 and >80.6 respectively (p value<0.001). Serum and urinary NGAL had correlation coefficient of 0.462 and 0.380 with p value 0.005 and 0.02 respectively. Serum and urinary neutrophil gelatinase associated lipocalin showed significant predictive values for requirement of hemodialysis (renal replacement therapy) with p-value of 0.007 and 0.003 respectively, using multivariate analysis. Serum and urinary neutrophil gelatinase associated lipocalin at values >136.5 and >131 respectively were found to predict mortality (p value<0.001).

Conclusion: Neutrophil gelatinase associated lipocalin correlates strongly with development of acute kidney injury and the various radiological changes. Thus, it can be used as a prognostic marker in severe COVID-19 disease.

చిన్న కమ్యూనికేషన్

Hypertension: A Rare Presentation and Risk Factors for Renal Cell Carcinoma

Lucy Lu

Renal cell carcinoma represents 3% of grown-up disease cases. This cancer can give an assortment of manifestations and signs, thus it is known as the internist growth. Renal cell carcinoma is additionally connected with a wide range of paraneoplastic syndromes. We report an instance of renal cell carcinoma with hypertension as a solitary introducing manifestation.
సంపాదకీయం

Developing Understanding and Surgical Management of Renal Cortical Tumors

Zahra Lotfi

A few variables, including cancer stage relocation, a worked on comprehension of the histologic subtypes, and new careful therapy procedures, are simultaneously affecting the surgical management of renal cortical tumors. The article Proceedings is both convenient and significant as we approach the careful administration of renal cancers today.
సంపాదకీయం

Overview on Pain Management in Polycystic Kidney Disease

Zahra Lotfi

Both acute and chronic pain is a common complaint in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). This generally normal of hereditary sicknesses brings about End-Stage Renal Disease (ESRD). The range of chronic in patients with ADPKD might be connected straight forwardly to renal blister development or confusions brought about by the enormous growths.

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