జర్నల్ ఆఫ్ మెటబాలిక్ సిండ్రోమ్

Objectives: Hypomagnesaemia and insulin resistance are two major clinical problems, with intertwining pathophysiology. We aimed to explore this association in obese patients and in non-insulin-treated patients with type 2 diabetes mellitus (T2DM).
Methods: Subjects were recruited from the outpatient diabetes/obesity clinic of the Antwerp University Hospital. The population (N=2731) consists of 2 subject groups with different degrees of insulin resistance and insulin secretory potential: 1) overweight (Body Mass index (BMI) ≥ 25 kg/m² and <30 kg/m²) and obese (BMI ≥ 30 kg/m²) subjects, 2) adult T2DM patients. Hypomagnesaemia was defined as serum magnesium <1.7 mg/dl. Insulin resistance was estimated using the Homeostasis model assessment (HOMA-IR; cut-off point 2.82).
Results: Hypomagnesaemia was present in 6.1% of the entire population. Patients with hypomagnesaemia had more visceral adipose tissue (VAT), and a higher HOMA-IR. They suffered more from the metabolic syndrome and T2DM. Patients with a HOMA-IR<2.82 were younger, had lower BMI and less VAT. They suffered less from hypomagnesaemia. Hypomagnesaemia was more prevalent in T2DM patients than in obese subjects without T2DM. Although serum magnesium and HOMA-IR were negatively correlated, logistic regression analysis showed that magnesium was not a significant predictor for HOMA-IR.
Conclusions: Despite a significant negative correlation between magnesium and HOMA-IR, magnesium was not retained as a significant determinant of insulin resistance compared to the other predictors in our population of obese subjects and T2DM patients.

Objectives: The global prevalence of Helicobacter pylori (H. pylori) infection remains high. Recent studies demonstrated the potential relationship among H. pylori-induced chronic inflammation, insulin resistance and metabolic disorders. The aim of this study was to investigate the association between H. pylori infection and metabolic syndrome (MetS).
Methods: This cross-sectional study enrolled 4,232 health examination participants aged from 30 to 65-year-old in the northern Taiwan in 10 years. The general information and blood tests of all subjects were collected from the health examination center. H. pylori infection was diagnosed via 13C-urea breath test. The log-transformed (log) serum high sensitivity C-reactive protein (hs-CRP) was used as the inflammatory parameter. MetS was defined according to the revised National Cholesterol Educational Program Adult Treatment Panel III (Revised NCEP ATP III) criteria. Subjects were divided into two groups based on their H. pylori infectious status. The association between H. pylori infection and metabolic parameters was assessed with multivariate logistic regression analysis.
Results: A total of 4,232 subjects (2,641 males and 1,591 females, aged 47.0 years ± 8.2 years) were enrolled for the analysis. H. pylori infection presented in 44.8% of all subjects. MetS presented in 27.6% of all subjects. Participants with H. pylori infection showed higher proportion of MetS, higher body mass index(BMI) and higher serum cholesterol(T-CHO) levels with statistical significance (p<0.001). There was no significant difference in the log serum hs-CRP between subjects with and without H. pylori infection. H. pylori infection increased the risk of large waist circumference component [OR=1.26 (1.10-1.43)] and high fasting plasma glucose component [OR=1.18 (1.04-1.34)], and contributed significantly to the presence of MetS with adjusted OR 1.23 (1.03-1.46).
Conclusions: Adults with H. pylori infection was associated with higher prevalence of MetS, higher BMI and higher mean serum T-CHO levels. Furthermore, H. pylori infection was identified as a risk factor for MetS.

Introduction: Diabetes causes a never-ending medicine and or insulin treatment for the diseased. Also, the patients are bound to follow a particular diet, with eliminating most of the sugary foods; that further deteriorates the quality of life. This gave way to the study, focused on diabetes cure without medicines and on rich fruits and vegetable diet. The clinical trial on 55 diabetes patients with a team of 6 medical associates was practiced for 3- days at Zorba, The Buddha, 10 – Tropical Drive, Ghitorni, New Delhi from 29th April to 1st May, 2016. The goal was to establish and observe the effects of plant-based diet on the sugar levels of the diabetes patients. These included both insulin-dependent and independent, diabetes type-1 and type-2 patients. The 3-days Residential Treatment Tour involved 55 subjects with different age groups and demographic profiles. The study considered participants from different countries to find out the global impact of the treatment.

Objective: The burden of the disease diabetes is rising globally. The aim of the research is to find out that on discontinuing the medicines and being on a particular plant-based diet, can high blood glucose levels in diabetes patients be normalized.

Methodology: Clinical trials were performed on diabetes patients for 3-days continuously. The sample size of the study was n=55 patients. Medicines were eliminated from the first day of the trial. Thereafter, following 3-days, the participants were kept on a prescribed plant-based diet. Both fasting and post-prandial readings were measured each day along with the weights of the participants. The subjects with varying diabetes history, age groups, type of diabetes, insulin dependency and demographic profiles were part of the trial.

Findings of the study: The study reported controlled* blood glucose levels for 84% of patients and partiallycontrolled* levels for 16% of patients. Those with controlled* levels could attain a healthy blood glucose range without medicines and or insulin, along with the prescribed diet in 3-days. Those with partially controlled* levels could attain a healthy blood glucose range with less than 50% of insulin than prescribed earlier. Among diabetes type-2 patients the study reported 100% results with all the patients maintaining a healthy blood glucose level. While among diabetes type-1 patients, 57% reported controlled* blood glucose levels through the diet and zeromedications. Whereas, 43% reported healthy blood sugar levels through the diet and insulin reduction. In addition of the insulin-dependent group, 59% could completely drop their insulin requirements and 41% could reduce the requirement to at least 50%. The weight reduction for 55 patients in 3-days was reported as 1.14 kgs of average weight loss per individual. Also, the patients had symptomatic relief from general fatigue and weaknesses. The plant-based diet proved to be beneficial with regards to energy and nutritional fulfillments.

Future scope: Diabetes treatment has both health and economic burden on society. With reference to the present research, a new approach for the treatment of this considered life-style metabolic disability can be shaped. The plant-based diet has been found effective to cure and control diabetes, eliminating the medicine or insulin requirements. Further research on the subject matter can present a medicine-free-food-science based treatment for the disease. At the same time, this unique treatment approach will eliminate the risks of medicine side-effects. On the basis of this research, diabetes education can be developed for better understanding of the disease and better living for the diseased population.