ఫుడ్ & ఇండస్ట్రియల్ మైక్రోబయాలజీ జర్నల్

Is Fragile X Syndrome Protective For Subsequent Cancers? A review of literature

Abstract

Mohammad vasei, Maryam Sotoudeh Anvari, Seyed javad Mowla, Saeede Salehi , Negin Hosseini Rouzbahani and Moeinadin Safavi

Fragile X Syndrome (FXS) is a key inherited basis of intellectual disability (ID) . It initiated by an expansion of over 200 CGG (cytosine-guanine-guanine) repeats in the 5 untranslated region (UTR) of the fragile X mental retardation 1 (FMR1) gene and consequently, the lack of fragile X mental retardation protein (FMRP) in the neurons causes developmental abnormalities in the brain.

Although one of the largest studies on cancer risk in patient with ID demonstrated increased risk of leukemia and gastrointestinal cancers, few existing articles in FXS tell us about decrease of cancer in these patients.

everyday many mechanism are described involving in FMR1 mRNA and FMRP interaction with other genes, and new information about cancer oncogenesis of FXS. This review summarizes the available articles and provides an overview of some databases contain data pertinent to cancer in this field.